Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

@article{Bulavin2001InitiationOA,
  title={Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase},
  author={Dmitry V Bulavin and Yuichiro Higashimoto and Ian J. Popoff and William A. Gaarde and Venkatesha Basrur and Olga Potapova and Ettore Appella and Albert J. Fornace},
  journal={Nature},
  year={2001},
  volume={411},
  pages={102-107}
}
Response to genotoxic stress can be considered as a multistage process involving initiation of cell-cycle arrest and maintenance of arrest during DNA repair. Although maintenance of G2/M checkpoints is known to involve Chk1, Chk2/Rad53 and upstream components, the mechanisms involved in its initiation are less well defined. Here we report that p38 kinase has a critical role in the initiation of a G2 delay after ultraviolet radiation. Inhibition of p38 blocks the rapid initiation of this… 
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