Initiation of Resuscitation with High Tidal Volumes Causes Cerebral Hemodynamic Disturbance, Brain Inflammation and Injury in Preterm Lambs

@inproceedings{Polglase2012InitiationOR,
  title={Initiation of Resuscitation with High Tidal Volumes Causes Cerebral Hemodynamic Disturbance, Brain Inflammation and Injury in Preterm Lambs},
  author={Graeme Roger Polglase and Suzanne L Miller and Samantha K. Barton and Ana A. Baburamani and Flora S Y Wong and James D S Aridas and Andrew William Gill and Timothy J. M. Moss and Mary Tolcos and Martin R. Kluckow and Stuart Brian Hooper},
  booktitle={PloS one},
  year={2012}
}
AIMS Preterm infants can be inadvertently exposed to high tidal volumes (V(T)) in the delivery room, causing lung inflammation and injury, but little is known about their effects on the brain. The aim of this study was to compare an initial 15 min of high V(T) resuscitation strategy to a less injurious resuscitation strategy on cerebral haemodynamics, inflammation and injury. METHODS Preterm lambs at 126 d gestation were surgically instrumented prior to receiving resuscitation with either: 1… CONTINUE READING