Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139.

@article{Rogakou2000InitiationOD,
  title={Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139.},
  author={Emmy P. Rogakou and Wilberto Nieves-Neira and Chye Boon and Yves Pommier and W. M. Bonner},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 13},
  pages={9390-5}
}
Histone H2AX is a ubiquitous member of the H2A histone family that differs from the other H2A histones by the presence of an evolutionarily conserved C-terminal motif, -KKATQASQEY. The serine residue in this motif becomes rapidly phosphorylated in cells and animals when DNA double-stranded breaks are introduced into their chromatin by various physical and chemical means. In the present communication we show that this phosphorylated form of H2AX, referred to as gamma-H2AX, appears during… CONTINUE READING

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