Initiation and termination of DNA replication in human rRNA genes.

@article{Little1993InitiationAT,
  title={Initiation and termination of DNA replication in human rRNA genes.},
  author={R. R. Holden Val Johnson Daniel Kaplan Harvey Keselma Little and Timothy H. K. Platt and C. L. Schildkraut},
  journal={Molecular and cellular biology},
  year={1993},
  volume={13 10},
  pages={6600-13}
}
We have used the multicopy human rRNA genes as a model system to study replication initiation and termination in mammalian chromosomes. Enrichment for replicating molecules was achieved by isolating S-phase enriched populations of cells by centrifugal elutriation, purification of DNA associated with the nuclear matrix, and a chromatographic procedure that enriches for molecules containing single-stranded regions, a characteristic of replication forks. Two-dimensional agarose gel electrophoresis… CONTINUE READING

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