Initiation and spread of epileptiform discharges in the methylazoxymethanol acetate rat model of cortical dysplasia: functional and structural connectivity between CA1 heterotopia and hippocampus/neocortex.

Abstract

Neuronal migration disorders (NMDs) are often associated with medically intractable epilepsy. In utero injection of methylazoxymethanol acetate into pregnant rats gives rise to dysplastic cell clusters ("heterotopia") in hippocampus (and nearby regions), providing an animal model of NMD. In the present study, we have examined the structural and functional… (More)

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Cite this paper

@article{Tschuluun2005InitiationAS, title={Initiation and spread of epileptiform discharges in the methylazoxymethanol acetate rat model of cortical dysplasia: functional and structural connectivity between CA1 heterotopia and hippocampus/neocortex.}, author={Naranzogt Tschuluun and Juergen Wenzel and Kimberley D Katleba and Phillip A. Schwartzkroin}, journal={Neuroscience}, year={2005}, volume={133 1}, pages={327-42} }