Initiation and perpetuation of rat adjuvant arthritis is inhibited by the anti-CD2 monoclonal antibody (mAb) OX34.

@article{Hoffmann1997InitiationAP,
  title={Initiation and perpetuation of rat adjuvant arthritis is inhibited by the anti-CD2 monoclonal antibody (mAb) OX34.},
  author={J{\"o}rg Hoffmann and C Herklotz and Hennig Zeidler and Bernd Bayer and Hannah Rosenthal and J{\"o}rg Westermann},
  journal={Annals of the rheumatic diseases},
  year={1997},
  volume={56 12},
  pages={716-22}
}
OBJECTIVE The purpose of this study was to investigate the therapeutic potential of the anti-CD2 mAb OX34 first with regard to bone protection in established rat adjuvant arthritis (AA) and secondly with regard to prevention of AA induction. METHODS Established AA was treated with dexamethasone (1 mg/kg body weight) for two days plus OX34 mAb or control mAb over three days (2 mg and then 1 mg) starting at different time points of the disease. For prevention studies animals were injected as… CONTINUE READING
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