Initiation and perpetuation of NLRP3 inflammasome activation and assembly.

  title={Initiation and perpetuation of NLRP3 inflammasome activation and assembly.},
  author={Eric I Elliott and Fayyaz Shiraz Sutterwala},
  journal={Immunological reviews},
  volume={265 1},
The NLRP3 (NOD-like receptor family, pyrin domain containing 3) inflammasome is a multiprotein complex that orchestrates innate immune responses to infection and cell stress through activation of caspase-1 and maturation of inflammatory cytokines pro-interleukin-1β (pro-IL-1β) and pro-IL-18. Activation of the inflammasome during infection can be protective, but unregulated NLRP3 inflammasome activation in response to non-pathogenic endogenous or exogenous stimuli can lead to unintended… CONTINUE READING
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