Initiation and modulation of locomotor circuitry output with multisite transcutaneous electrical stimulation of the spinal cord in noninjured humans.

@article{Gerasimenko2015InitiationAM,
  title={Initiation and modulation of locomotor circuitry output with multisite transcutaneous electrical stimulation of the spinal cord in noninjured humans.},
  author={Yury P. Gerasimenko and Ruslan Gorodnichev and Aleksandr Puhov and Tatiana R. Moshonkina and Aleksandr Savochin and Victor A. Selionov and Roland R. Roy and Daniel C. Lu and V. Reggie Edgerton},
  journal={Journal of neurophysiology},
  year={2015},
  volume={113 3},
  pages={
          834-42
        }
}
The mammalian lumbar spinal cord has the capability to generate locomotor activity in the absence of input from the brain. Previously, we reported that transcutaneous electrical stimulation of the spinal cord at vertebral level T11 can activate the locomotor circuitry in noninjured subjects when their legs are placed in a gravity-neutral position (Gorodnichev RM, Pivovarova EA, Pukhov A, Moiseev SA, Savokhin AA, Moshonkina TR, Shcherbakova NA, Kilimnik VA, Selionov VA, Kozlovskaia IB, Edgerton… 
View on PubMed
jn.physiology.org
100 Citations
Highly Influential Citations
5
Background Citations
30
Methods Citations
11
Results Citations
2

Figures and Tables from this paper

100 Citations

Citation Type

Citation Type

Transcutaneous electrical spinal-cord stimulation in humans.
Modulation of upper limb locomotor function via transcutaneous electrical stimulation of spinal cord nervous system
TLDR
From the EMG map, it is found that spinal cord segments C5, C6 and C7 are highly relevant to biceps brachii muscle and the multi-sites TcESCS has a larger EMG response than single site.
Integration of sensory, spinal, and volitional descending inputs in regulation of human locomotion.
TLDR
The hypothesis that spinal and plantar stimulation may be effective tools for enhancing the recovery of motor control in individuals with neurological injuries and disorders is supported.
Studies of Interactions between Limbs in Humans Subjected to Noninvasive Electrical Stimulation of the Spinal Cord
TLDR
The effects of activation of spinal locomotor centers at the cervical and lumbar levels on interlimb synergies were studied in humans and may be useful for developing a neurorehabilitation method for patients with impaired motor function.
Spinal and sensory neuromodulation of spinal neuronal networks in humans
TLDR
It is found that plantar pressure stimulation and/or spinal stimulation can effectively facilitate locomotor output in the subjects placed with their legs in gravity neutral position and synergistic effects of combining sensory and spinal cord stimulation are shown, suggesting that the two networks are different, but complementary.
Electrical Spinal Stimulation, and Imagining of Lower Limb Movements to Modulate Brain-Spinal Connectomes That Control Locomotor-Like Behavior
TLDR
The data suggest that the ongoing assessment of the environment within the supraspinal centers that play a role in planning a movement can routinely modulate the physiological state of spinal networks that further facilitates a synergistic neuromodulation of the brain and spinal cord in preparing for movements.
SENSORIMOTOR REGULATION OF MOVEMENTS: NOVEL STRATEGIES FOR THE RECOVERY OF MOBILITY.
TLDR
It is found that a combination of a novel non-invasive transcutaneous spinal cord stimulation and sensory-motor stimulation of leg mechanoreceptors can modulate the spinal locomotor circuitry to that enables voluntary rhuthmic locomotor movements.
Mapping of the Spinal Sensorimotor Network by Transvertebral and Transcutaneous Spinal Cord Stimulation
TLDR
The electrophysiological mapping demonstrated that transvertebral SCS has specific effects to the rostrocaudally distributed sensorimotor network of the lower thoracic and lumbosacral cord, mainly by stimulation of the roots that carry the sensory and motor spinal pathways.
Simultaneous Cervical and Lumbar Spinal Cord Stimulation Induces Facilitation of Both Spinal and Corticospinal Circuitry in Humans
TLDR
It is demonstrated, for the first time, that tonic activation of spinal cord networks through multiple sites of tSCS provides a facilitation of both spinal reflex and corticospinal pathways.
Sensorimotor regulation of movements: Novel strategies for the recovery of mobility
TLDR
It is found that a combination of a novel non-invasive transcutaneous spinal cord stimulation and sensory-motor stimulation of leg mechanoreceptors can modulate the spinal locomotor circuitry to state that enables voluntary rhythmic locomotor movements.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 70 REFERENCES
Novel and Direct Access to the Human Locomotor Spinal Circuitry
TLDR
It is suggested that SEMS could be an effective noninvasive clinical tool to determine the potential of an individual to recover locomotion after a spinal cord injury, as well as being an effective rehabilitation tool itself.
On the central generation of locomotion in the low spinal cat
TLDR
A central network of neurones in the spinal cord has been shown to produce a rhythmic motor output similar to locomotion after suppression of all afferent inflow, and it is concluded that there is at least one network for each limb.
Propriospinal neurons are sufficient for bulbospinal transmission of the locomotor command signal in the neonatal rat spinal cord
TLDR
The results suggest that propriospinal neurons are sufficient for transmission of descending locomotor command signals, which has implications for regeneration strategies aimed at restoration of locomotor function after spinal cord injury.
Locomotor-Related Networks in the Lumbosacral Enlargement of the Adult Spinal Cat: Activation Through Intraspinal Microstimulation
TLDR
Investigation of the use of low-level tonic intraspinal microstimulation as a means of activating spinal locomotor networks in adult cats with complete spinal transections found it more effective in eliciting alternating movements in the hindlimbs than stimulation in the rostral regions.
Propriospinal Circuitry Underlying Interlimb Coordination in Mammalian Quadrupedal Locomotion
TLDR
In the newborn rat, a caudorostral propriospinal excitability gradient appears to mediate interlimb coordination, which relies more on asymmetric axial connectivity between the lumbar and cervical generators than on differences in their inherent rhythmogenic capacities.
Use of quadrupedal step training to re-engage spinal interneuronal networks and improve locomotor function after spinal cord injury.
TLDR
The results provide strong evidence that actively engaging the forelimbs improves hindlimb function and that one likely mechanism underlying these effects is the reorganization and re-engagement of rostrocaudal spinal interneuronal networks.
Cervicolumbar Coordination in Mammalian Quadrupedal Locomotion: Role of Spinal Thoracic Circuitry and Limb Sensory Inputs
TLDR
In the newborn rat, anteroposterior limb coordination relies on active burst generation within midcord thoracic circuitry that additionally conveys ascending and weaker descending coupling influences of distant limb proprioceptive inputs to the cervical and lumbar generators, respectively.
Human lumbar cord circuitries can be activated by extrinsic tonic input to generate locomotor-like activity.
Significance of peripheral feedback in the generation of stepping movements during epidural stimulation of the spinal cord
TLDR
Data show that peripheral feedback during epidural stimulation of the spinal cord can define the properties of the motor output.
Characteristics and mechanisms of locomotion induced by intraspinal microstimulation and dorsal root stimulation in spinal cats.
TLDR
The integrity of the ventral or ventrolateral funiculi as well as the L(3)-L(4) segments are critical for the induction of locomotion by ISMS at L(5) to S(1) or by DRS at these caudal segments.
...
1
2
3
4
5
...