Initiation, elongation, and termination strategies in polyketide and polypeptide antibiotic biosynthesis.

@article{Keating1999InitiationEA,
  title={Initiation, elongation, and termination strategies in polyketide and polypeptide antibiotic biosynthesis.},
  author={Thomas A. Keating and Christopher T Walsh},
  journal={Current opinion in chemical biology},
  year={1999},
  volume={3 5},
  pages={598-606}
}
Progress in sequence analysis of biosynthetic gene clusters encoding polyketides and nonribosomal peptides and in the reconstitution of in vitro activities continues to reveal new insights into the growth of these natural products' acyl chains, which have been revealed as a series of elongating, covalent, acyl enzyme intermediates on their multimodular scaffolds. Studies that focus on the three stages of natural product biosynthesis - initiation, elongation, and termination - have yielded… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 42 extracted citations

Similar Papers

Loading similar papers…