Initiating oncogenic event determines gene-expression patterns of human breast cancer models.

@article{Desai2002InitiatingOE,
  title={Initiating oncogenic event determines gene-expression patterns of human breast cancer models.},
  author={Kartiki V Desai and Nianqing Xiao and Weili Wang and Lisa M Gangi and John Greene and John I. Powell and Robert L Dickson and Priscilla Furth and Kent Hunter and Raju Kucherlapati and Richard Simon and Edison T. Liu and Jeffrey E. Green},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 10},
  pages={6967-72}
}
Molecular expression profiling of tumors initiated by transgenic overexpression of c-myc, c-neu, c-ha-ras, polyoma middle T antigen (PyMT) or simian virus 40 T/t antigen (T-ag) targeted to the mouse mammary gland have identified both common and oncogene-specific events associated with tumor formation and progression. The tumors shared great similarities in their gene-expression profiles as compared with the normal mammary gland with an induction of cell-cycle regulators, metabolic regulators… CONTINUE READING
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