Initiating morphological changes associated with long-term facilitation in Aplysia is independent of transcription or translation in the cell body.

@article{Grabham2005InitiatingMC,
  title={Initiating morphological changes associated with long-term facilitation in Aplysia is independent of transcription or translation in the cell body.},
  author={Peter W. Grabham and Fang Wu and Samuel Schacher and Daniel J. Goldberg},
  journal={Journal of neurobiology},
  year={2005},
  volume={64 2},
  pages={
          202-12
        }
}
In Aplysia, the growth of axonal arbor and the formation of new presynaptic varicosities are thought to contribute to long-term facilitation (LTF) produced by serotonin (5-HT). While it is known that there is a requirement for both transcription and translation in LTF and in the accompanying morphological changes, the mechanisms mediating the initiation and maintenance of these changes are poorly understood. We used long-term labeling of the presynaptic sensory neuron to carry out repeated… CONTINUE READING
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