Initiating meiosis: the case for retinoic acid.

  title={Initiating meiosis: the case for retinoic acid.},
  author={Michael D Griswold and Cathryn A. Hogarth and Josephine Bowles and Peter Koopman},
  journal={Biology of reproduction},
  volume={86 2},
The requirement for vitamin A in reproduction and development was first determined from studies of nutritional deficiencies. Subsequent research has shown that embryonic development and both male and female reproduction are modulated by retinoic acid (RA), the active form of vitamin A. Because RA is active in multiple developmental systems, its synthesis, transport, and degradation are tightly regulated in different tissues. A growing body of evidence implicates RA as a requirement for the… CONTINUE READING
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