Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia.

  title={Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia.},
  author={Dengli Hong and Rajeev Gupta and Philip James Ancliff and Ann Kathleen Atzberger and John W. S. Brown and Shamit Soneji and Joanne Connor Green and Sue Colman and Wanda Piacibello and Veronica J. Buckle and Shinobu Tsuzuki and Mel Greaves and Tariq Enver},
  volume={319 5861},
Understanding cancer pathogenesis requires knowledge of not only the specific contributory genetic mutations but also the cellular framework in which they arise and function. Here we explore the clonal evolution of a form of childhood precursor-B cell acute lymphoblastic leukemia that is characterized by a chromosomal translocation generating a TEL-AML1 fusion gene. We identify a cell compartment in leukemic children that can propagate leukemia when transplanted in mice. By studying a… CONTINUE READING


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