Initiating activity of the anti-estrogen tamoxifen, but not toremifene in rat liver.

@article{Williams1997InitiatingAO,
  title={Initiating activity of the anti-estrogen tamoxifen, but not toremifene in rat liver.},
  author={Gary M Williams and Michael J. Iatropoulos and Stefan Karlsson},
  journal={Carcinogenesis},
  year={1997},
  volume={18 11},
  pages={2247-53}
}
A striking difference between two structurally related anti-estrogen medicines is that tamoxifen is strongly hepatocarcinogenic in the rat, whereas toremifene lacks such activity. To study the basis for this difference, the initiating potential of tamoxifen and toremifene were studied by measurement of rapid induction of hepatocellular altered foci (HAF) that express placental-type glutathione S-transferase in the livers of female Sprague-Dawley (S-D) rats and female Fischer 344 (F344) rats… CONTINUE READING