Initial testing (stage 1) of the PARP inhibitor BMN 673 by the pediatric preclinical testing program: PALB2 mutation predicts exceptional in vivo response to BMN 673.

@article{Smith2015InitialT,
  title={Initial testing (stage 1) of the PARP inhibitor BMN 673 by the pediatric preclinical testing program: PALB2 mutation predicts exceptional in vivo response to BMN 673.},
  author={Malcolm A Smith and Oliver A. Hampton and C Patrick Reynolds and Min Ho Kang and John M. Maris and Richard Greg Gorlick and Edward Anders Kolb and Richard B. Lock and Hernan Carol and Stephen T Keir and Jianrong Wu and Raushan T Kurmasheva and David A. Wheeler and Peter James Houghton},
  journal={Pediatric blood & cancer},
  year={2015},
  volume={62 1},
  pages={91-8}
}
BACKGROUND BMN 673 is a potent inhibitor of poly-ADP ribose polymerase (PARP) that is in clinical testing with a primary focus on BRCA-mutated cancers. BMN 673 is active both through inhibiting PARP catalytic activity and by tightly trapping PARP to DNA at sites of single strand breaks. PROCEDURE BMN 673 was tested in vitro at concentrations ranging from 0.1 nM to 1 μM and in vivo at a daily dose of 0.33 mg/kg administered orally twice daily (Mon-Fri) and once daily on weekends (solid tumors… CONTINUE READING
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