Initial synaptic efficacy influences induction and expression of long-term changes in transmission.

@article{Yang1991InitialSE,
  title={Initial synaptic efficacy influences induction and expression of long-term changes in transmission.},
  author={Xiang D. Yang and Donald S. Faber},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 10},
  pages={4299-303}
}
Long-term depression (LTD) of glutamatergic and electrotonic transmission can be induced at mixed synapses between eighth nerve fibers and the goldfish Mauthner (M) cell in vivo, by pairing weak presynaptic tetani with postsynaptic inhibition. This LTD can be reversed by stronger tetani that produce long-term potentiation (LTP). Moreover, the depression is more likely to occur and tends to last longer when the initial synaptic efficacy is high--that is, if the synaptic strength is first… CONTINUE READING
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