Initial sequencing and comparative analysis of the mouse genome

  title={Initial sequencing and comparative analysis of the mouse genome},
  author={Robert H. Waterston and Kerstin Lindblad-Toh and Ewan Birney and Jane Rogers and Josep F. Abril and Pankaj Agarwal and Richa Agarwala and Rachel Ainscough and Marina Alexandersson and Peter An and Stylianos E. Antonarakis and John Attwood and Robert Baertsch and Jeannie Bailey and Kyle Barlow and Stephan Beck and Eric Berry and Bruce Birren and Toby Bloom and Peer Bork and Marc R M Botcherby and Nicolas L Bray and Michael R. Brent and Daniel G. Brown and Stephen Douglas Brown and Carol C. Bult and John Burton and J. Butler and Robert D. Campbell and Piero Carninci and Simon Cawley and Francesca Chiaromonte and Asif T. Chinwalla and Deanna M. Church and Michele Clamp and Christopher M Clee and Francis S. Collins and Lisa L. Cook and Richard R Copley and Alan R. Coulson and Olivier Couronne and James Cuff and Val Curwen and Tim Cutts and Mark Daly and Robert David and Joy Davies and Kimberly D. Delehaunty and Justin Deri and Emmanouil T. Dermitzakis and Colin N. Dewey and Nicholas J. Dickens and Mark Diekhans and Sheila Dodge and Inna Dubchak and Diane Marie Dunn and Sean R. Eddy and Laura Elnitski and Richard D Emes and Pallavi Eswara and Eduardo Eyras and Adam L. Felsenfeld and Ginger A. Fewell and Paul Flicek and Karen Foley and Wayne N. Frankel and Lucinda A. Fulton and Robert S. Fulton and Terrence S. Furey and Dennis Gage and Richard A. Gibbs and Gustavo Glusman and Sante Gnerre and Nick Goldman and Leo Goodstadt and Darren Grafham and Tina A. Graves and Eric D. Green and Simon G. Gregory and Roderic Guig{\'o} and Mark Guyer and Ross C. Hardison and David Haussler and Yoshihide Hayashizaki and LaDeana W. Hillier and Angela S. Hinrichs and Wratko Hlavina and Timothy J. Holzer and Fan Hsu and Axin Hua and Tim Hubbard and A. Hunt and Ilya Jackson and David B. Jaffe and Leslie S. Johnson and Micheal Jones and Thomas A. Jones and Ann Mary Joy and Michael Kamal and Elinor K Karlsson and Donna Karolchik and Aleksander Kasprzyk and Jun Kawai and Evan Keibler and Cristyn Kells and W. James Kent and Andrew Kirby and Diana L. Kolbe and Ian Korf and Raju S. Kucherlapati and Edward J. Kulbokas and David Kulp and Tom Landers and James P L Leger and Steven Leonard and Ivica Letunic and Rosie Levine and Jongming Li and Meishan Li and Christine Lloyd and Susan B. Lucas and Bin Ma and Donna R. Maglott and Elaine R. Mardis and Lucy Matthews and Evan Mauceli and John H. Mayer and M. Mccarthy and W. Richard McCombie and Stuart R. McLaren and Kirsten McLay and John D. McPherson and Jim Meldrim and Beverley Meredith and Jill P. Mesirov and Webb Miller and Tracie L. Miner and Emmanuel Mongin and Kate T. Montgomery and Michael Morgan and Richard Mott and James C. Mullikin and Donna M. Muzny and William E. Nash and Joanne O. Nelson and Michael N. Nhan and Robert A. Nicol and Zemin Ning and Chad Nusbaum and Michael John O'connor and Yasushi Okazaki and Karen L. Oliver and E. K. Overton-Larty and Lior Pachter and Gen{\'i}s Parra and Kymberlie H. Pepin and Jane Eloise Peterson and Pavel A. Pevzner and Robert H. Plumb and Craig S. Pohl and Alex Poliakov and Tracy C Ponce and Chris Paul Ponting and Susan Potter and Michael A. Quail and Alexandre Reymond and B. A. Roe and Krishna M. Roskin and Edward M. Rubin and Alistair G. Rust and Ralph Santos and Victor Sapojnikov and Brian Schultz and Joerg Schultz and Matthias S Schwartz and Scott Schwartz and Carol Scott and Steven Seaman and Steve Searle and Ted Sharpe and Andrew Sheridan and Ratna Shownkeen and Sarah Sims and Jonathan Noam Singer and Guy Slater and Arian Smit and Douglas R. Smith and Brian Spencer and Arne Stabenau and Nicole Stange-thomann and Charles Sugnet and Mikita Suyama and Glenn Tesler and Johanna Thompson and David Torrents and Evanne Trevaskis and John Tromp and Catherine Ucla and Abel Ureta-Vidal and Jade P. Vinson and Andrew von Niederhausern and Claire M. Wade and Melanie Wall and R. J. Weber and Robert B Weiss and Michael C. Wendl and Anthony P. West and Kris A. Wetterstrand and Raymond Wheeler and Simon Whelan and Jamey M Wierzbowski and David Willey and S. Williams and Richard K. Wilson and Eitan Winter and Kim C Worley and Dudley Wyman and Shan Yang and Shiaw-Pyng Yang and Evgeny M. Zdobnov and Michael C. Zody and Eric S. Lander},
The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial comparative analysis of the mouse and human genomes, describing some of the insights that can be gleaned from the two sequences. We discuss topics including the analysis of the… CONTINUE READING


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