Initial sensitivity, tolerance and cross-tolerance to allopregnanolone- and ethanol-induced hypothermia in selected mouse lines

Abstract

Abstract Rationale. Acute ethanol administration induces hypothermia in genetically susceptible animals. Tolerance to this effect may develop with repeated administration. Allopregnanolone is an endogenously produced neuroactive steroid that acts at the GABA-A receptor. We postulated that allopregnanolone would induce hypothermia, and that lines of mice… (More)
DOI: 10.1007/s00213-002-1106-2

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@article{Palmer2002InitialST, title={Initial sensitivity, tolerance and cross-tolerance to allopregnanolone- and ethanol-induced hypothermia in selected mouse lines}, author={Abraham A Palmer and Michelle R. Moyer and J Christopher F Crabbe and Tamara J Phillips}, journal={Psychopharmacology}, year={2002}, volume={162}, pages={313-322} }