Initial recruitment of interferon-gamma-producing CD8+ effector cells, followed by infiltration of CD4+ cells in 2,4,6-trinitro-1-chlorobenzene (TNCB)-induced murine contact hypersensitivity reactions.

@article{Okazaki2002InitialRO,
  title={Initial recruitment of interferon-gamma-producing CD8+ effector cells, followed by infiltration of CD4+ cells in 2,4,6-trinitro-1-chlorobenzene (TNCB)-induced murine contact hypersensitivity reactions.},
  author={Fusako Okazaki and Hiroko Kanzaki and Kazuyasu Fujii and Jirĵ Arata and Hitoshi Akiba and Kazuhide Tsujii and K Iwatsuki},
  journal={The Journal of dermatology},
  year={2002},
  volume={29 11},
  pages={699-708}
}
Contact hypersensitivity (CHS) is an antigen-specific, T-cell-mediated skin reaction in sensitized individuals. Recent studies have demonstrated that the murine CHS reaction to 2,4-dinitrofluorobenzene (DNCB) is mediated by CD8+ T cells and down-regulated by CD4+ T cells. We studied cellular events and functions of infiltrating cells in CHS reactions to 2,4… CONTINUE READING