Initial non-compliance with antihypertensive monotherapy is followed by complete discontinuation of antihypertensive therapy.

@article{Wijk2006InitialNW,
  title={Initial non-compliance with antihypertensive monotherapy is followed by complete discontinuation of antihypertensive therapy.},
  author={Boris L G van Wijk and Olaf H Klungel and Eibert Roelof Heerdink and Anthonius de Boer},
  journal={Pharmacoepidemiology and drug safety},
  year={2006},
  volume={15 8},
  pages={587-93}
}
PURPOSE Discontinuation with treatment is a major problem in the treatment of hypertension. The objective of our study was to assess the association between non-compliance and discontinuation in patients who started using antihypertensive monotherapy. METHODS A nested case-control study within a cohort of new users of antihypertensive drugs between 1st January 1999 and 31st December 2002 was performed. We used data from the PHARMO database, a record linkage system containing drug-dispensing… CONTINUE READING

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