Initial monoamine oxidase-A inhibition by moclobemide does not predict the therapeutic response in patients with major depression

@article{Radat2008InitialMO,
  title={Initial monoamine oxidase-A inhibition by moclobemide does not predict the therapeutic response in patients with major depression},
  author={Françoise Radat and Ivan Berlin and Odile Spreux-Varoquaux and Skander Elatki and Maurice Ferreri and Alain Jacques Puech},
  journal={Psychopharmacology},
  year={2008},
  volume={127},
  pages={370-376}
}
It is generally accepted that the clinical efficacy of monoamine oxidase inhibitors (MAOI) is related to inhibition of this enzyme. In order to evaluate the predictive ability of monoamine oxidase-A inhibition for therapeutic efficacy, the start of treatment effects of moclobemide, a selective, reversible monoamine oxidase-A inhibitor, on plasma concentrations of monoamines and monoamine metabolites were determined. The plasma levels of 3,4-dihydroxy-phenylglycol (DHPG, deaminated metabolite of… Expand
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