Initial membrane reaction in peptidoglycan synthesis. Lipid dependence of phospho-n-acetylmuramyl-pentapeptide translocase (exchange reaction).

@article{Pless1973InitialMR,
  title={Initial membrane reaction in peptidoglycan synthesis. Lipid dependence of phospho-n-acetylmuramyl-pentapeptide translocase (exchange reaction).},
  author={D D Pless and Francis C. Neuhaus},
  journal={The Journal of biological chemistry},
  year={1973},
  volume={248 5},
  pages={
          1568-76
        }
}
Abstract The initial membrane reaction in the biosynthesis of peptidoglycan is catalyzed by phospho-N-acetylmuramyl-pentapeptide translocase (UDP-MurNAc - l - Ala - d - γ-Glu - l - Lys - d - Ala - d - Ala:undecaprenyl - phosphate phospho - MurNAc-pentapeptide transferase). In addition to the transfer reaction, the enzyme catalyzes the exchange of [3H]uridine monophosphate with the uridine monophosphate moiety of UDP - MurNAc - pentapeptide. Lipid-dependent translocase was obtained in an… CONTINUE READING

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