Initial management of severe hemorrhage with an oxygen-carrying hypertonic saline solution.

@article{Figueiredo2001InitialMO,
  title={Initial management of severe hemorrhage with an oxygen-carrying hypertonic saline solution.},
  author={Luiz Francisco Poli de Figueiredo and R J Cruz and Augusto Cardinalli Neto and Margareth Macae Yada-Langui and Maur{\'i}cio Rocha e Silva},
  journal={Artificial organs},
  year={2001},
  volume={25 11},
  pages={922-7}
}
We tested the hypothesis that the combination of polymerized bovine hemoglobin (PBHg) with hypertonic saline may be beneficial for the initial management of hemorrhagic shock in 22 mongrel dogs (15 +/- 1 kg) bled to a mean arterial pressure (MAP) of 40 mm Hg in 5 min and maintained at this level for 45 min (shed blood volume approximately 50 ml/kg). Animals were treated with a 4 ml/kg bolus over 4 min of one of the following fluids: whole blood, 7.5% NaCl (HS), 13 g/dl of PBHg, or 7.5% NaCl… CONTINUE READING