Initial management of immune thrombocytopenic purpura in adults: a randomized controlled trial comparing intermittent anti-D with routine care.

@article{George2003InitialMO,
  title={Initial management of immune thrombocytopenic purpura in adults: a randomized controlled trial comparing intermittent anti-D with routine care.},
  author={James N George and Gary E. Raskob and Sara K. Vesely and Dennis Moore and Roger M. Lyons and E Berrobianco Cobos and Brenda L Towell and Panpit P Klug and Troy H. Guthrie},
  journal={American journal of hematology},
  year={2003},
  volume={74 3},
  pages={161-9}
}
We conducted a randomized clinical trial in adults with a new diagnosis of ITP and a platelet count <30000/muL to test the hypothesis that initial intermittent treatment with anti-D may avoid or defer the need for splenectomy when compared to current routine care (glucocorticoid treatment, followed by splenectomy). Splenectomy was to be performed in the anti-D group if patients failed to respond to three consecutive anti-D treatments given within 10 days. The incidences of splenectomy were 14… CONTINUE READING

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