Initial low-dose gentamicin for Staphylococcus aureus bacteremia and endocarditis is nephrotoxic.

@article{Cosgrove2009InitialLG,
  title={Initial low-dose gentamicin for Staphylococcus aureus bacteremia and endocarditis is nephrotoxic.},
  author={S. E. Cosgrove and Gloria A. Vigliani and Vance G. Fowler and Elias Abrutyn and G. Ralph Corey and Donald P. Levine and Mark E. Rupp and Henry F. Chambers and Adolf W. Karchmer and Helen W. Boucher},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2009},
  volume={48 6},
  pages={713-21}
}
BACKGROUND The safety of adding initial low-dose gentamicin to antistaphylococcal penicillins or vancomycin for treatment of suspected Staphylococcus aureus native valve endocarditis is unknown. This study evaluated the association between this practice and nephrotoxicity. METHODS We performed a prospective cohort study of safety data from a randomized, controlled trial of therapy for S. aureus bacteremia and native valve infective endocarditis involving 236 patients from 44 hospitals in 4… CONTINUE READING
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