Initial hyperproliferation and incomplete terminal differentiation of cultured human keratinocytes from lesional and uninvolved psoriatic skin.

@article{Detmar1990InitialHA,
  title={Initial hyperproliferation and incomplete terminal differentiation of cultured human keratinocytes from lesional and uninvolved psoriatic skin.},
  author={Michael Detmar and A J Mayer-da-Silva and Rudolf Stadler and Constantin E. Orfanos},
  journal={Acta dermato-venereologica},
  year={1990},
  volume={70 4},
  pages={295-9}
}
Human epidermal keratinocytes (KCs) were isolated from lesional and from uninvolved skin of 8 patients with chronic plaque-like psoriasis and from the normal skin of 8 healthy volunteers. Primary KC cultures, grown on 3T3 cell feeder layers, were examined over a period of 4 weeks and their plating efficiency, colony growth area, DNA synthesis and… CONTINUE READING