Initial genome scan of the NIMH genetics initiative bipolar pedigrees: chromosomes 4, 7, 9, 18, 19, 20, and 21q.

@article{DeteraWadleigh1997InitialGS,
  title={Initial genome scan of the NIMH genetics initiative bipolar pedigrees: chromosomes 4, 7, 9, 18, 19, 20, and 21q.},
  author={S. D. Detera-Wadleigh and Judith A. Badner and Takeo Yoshikawa and Alan R. Sanders and Lynn R Goldin and Gillian Turner and Dorothy Rollins and Tracy Y. Moses and Juliet Guroff and Diane Kazuba and Melvin E. Maxwell and Howard J. Edenberg and Tatiana Foroud and Diya Lahiri and John J I Nurnberger and Oscar Colin Stine and Francis J. McMahon and Deborah A. Meyers and Dean F Mackinnon and Sheila E Simpson and Melvin G. McInnis and J Raymond Depaulo and John P. Rice and Alison M. Goate and Elliot S. Gershon},
  journal={American journal of medical genetics},
  year={1997},
  volume={74 3},
  pages={254-62}
}
An initial genome scan was performed on 540 individuals from 97 families segregating bipolar disorder, collected through the National Institutes of Mental Health Genetics Initiative. We report here affected-sib-pair (ASP) data on 126 marker loci (approximately 68,000 genotypes) mapping to chromosomes 4, 7, 9, 18, 19, 20, and 21q, under three affection status models. Modest increases in identical-by-descent (IBD) allele sharing were found at the following loci: D4S2397 and D4S391 (P < 0.05) on… CONTINUE READING

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