Initial genetic characterization of the 1918 "Spanish" influenza virus.

  title={Initial genetic characterization of the 1918 "Spanish" influenza virus.},
  author={Jeffery K. Taubenberger and Ann H. Reid and Amy E. Krafft and Karen E. Bijwaard and Thomas G. Fanning},
  volume={275 5307},
The "Spanish" influenza pandemic killed at least 20 million people in 1918-1919, making it the worst infectious pandemic in history. Understanding the origins of the 1918 virus and the basis for its exceptional virulence may aid in the prediction of future influenza pandemics. RNA from a victim of the 1918 pandemic was isolated from a formalin-fixed, paraffin-embedded, lung tissue sample. Nine fragments of viral RNA were sequenced from the coding regions of hemagglutinin, neuraminidase… CONTINUE READING
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