Initial experience with bosentan therapy in patients with the Eisenmenger syndrome.

@article{Christensen2004InitialEW,
  title={Initial experience with bosentan therapy in patients with the Eisenmenger syndrome.},
  author={Douglas D. Christensen and M. E. Mcconnell and Wendy Book and William T. Mahle},
  journal={The American journal of cardiology},
  year={2004},
  volume={94 2},
  pages={
          261-3
        }
}
Bosentan, an endothelin-1 antagonist that can be administered orally, has been shown to be effective in the treatment of idiopathic pulmonary arterial hypertension and may be of benefit to patients with the Eisenmenger syndrome. Nine patients with Eisenmenger's syndrome were treated with bosentan at a dose of 125 mg twice a day. After treatment with bosentan, 6 of 9 patients (67%) had an improvement in New York Heart Assocation classification of >/=1 grades (p = 0.03). Oxygen saturation levels… CONTINUE READING
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