Initial events in infectious salmon anemia virus infection: evidence for the requirement of a low-pH step.

@article{Eliassen2000InitialEI,
  title={Initial events in infectious salmon anemia virus infection: evidence for the requirement of a low-pH step.},
  author={T M Eliassen and Marianne K Fr\oystad and Birgit Helene Dannevig and Magdalena Jankowska and Andreas Brech and Knut Falk and Kristine Rom\oren and Tor Gj\oen},
  journal={Journal of virology},
  year={2000},
  volume={74 1},
  pages={218-27}
}
We have investigated the initial steps in the interaction between infectious salmon anemia virus (ISAV) and cultured cells from Atlantic salmon (SHK-1 cell line). Using radioactively or fluorescently labelled viral particles we have studied the binding and fusion kinetics and the effect of pH on binding, uptake, and fusion of ISAV to SHK-1 cells and liposomes. As pH in the medium was reduced from 7.5 to 4.5, the association of virus to the cells was nearly doubled. The same effect of pH was… CONTINUE READING

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