Initial evaluation of Cu-64 labeled PARPi-DOTA PET imaging in mice with mesothelioma.

Abstract

Poly(ADP-ribose) polymerase (PARP) has emerged as an important molecular target for the treatment of several oncological diseases. A couple of molecular probes based on Olaparib scaffold have been developed by incorporation of F-18 or fluorophore for positron emission tomography (PET) or optical imaging in several types of tumor. PARP has been reported… (More)
DOI: 10.1016/j.bmcl.2017.05.077

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