Initial evaluation in healthy humans of [18F]DPA-714, a potential PET biomarker for neuroinflammation.

  title={Initial evaluation in healthy humans of [18F]DPA-714, a potential PET biomarker for neuroinflammation.},
  author={Nicolas Arlicot and Johnny Vercouillie and Maria-Joao Ribeiro and Clovis Tauber and Yann Venel and Jean-Louis Baulieu and Serge Maia and Philippe Corcia and Michael G. Stabin and Aaron J Reynolds and Michael Kassiou and Denis Guilloteau},
  journal={Nuclear medicine and biology},
  volume={39 4},
INTRODUCTION The translocator protein 18 kDa (TSPO), although minimally expressed in healthy brain, is up-regulated in pathological conditions, coinciding with microglial activation. It is thereby a suitable in vivo biomarker of neuroinflammation for detection, evaluation and therapeutic monitoring of brain diseases. We aimed to estimate the radiation dosimetry of the positron emission tomography (PET) TSPO radioligand [(18)F]DPA-714, and we evaluated in healthy volunteers its whole-body uptake… CONTINUE READING


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