Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2.

@article{Watanabe2000InitialEF,
  title={Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2.},
  author={R. T. Watanabe and Yoshiko Murakami and Mina D Marmor and Norimitsu Inoue and Yusuke Maeda and Jun Hino and Kenji Kangawa and Michael Julius and Taroh Kinoshita},
  journal={The EMBO journal},
  year={2000},
  volume={19 16},
  pages={4402-11}
}
Glycosylphosphatidylinositols (GPIs) are attached to the C-termini of many proteins, thereby acting as membrane anchors. Biosynthesis of GPI is initiated by GPI-N-acetylglucosaminyltransferase (GPI-GnT), which transfers N-acetylglucosamine from UDP- N-acetylglucosamine to phosphatidylinositol. GPI-GnT is a uniquely complex glycosyltransferase, consisting of at least four proteins, PIG-A, PIG-H, PIG-C and GPI1. Here, we report that GPI-GnT requires another component, termed PIG-P, and that DPM2… CONTINUE READING

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