Initial deployment of the cardiogenic gene regulatory network in the basal chordate, Ciona intestinalis.

@article{Woznica2012InitialDO,
  title={Initial deployment of the cardiogenic gene regulatory network in the basal chordate, Ciona intestinalis.},
  author={Arielle Woznica and Maximilian H{\"a}u\ssler and Ella Starobinska and Jessica Jemmett and Younan Li and David R Mount and Brad Davidson},
  journal={Developmental biology},
  year={2012},
  volume={368 1},
  pages={127-39}
}
The complex, partially redundant gene regulatory architecture underlying vertebrate heart formation has been difficult to characterize. Here, we dissect the primary cardiac gene regulatory network in the invertebrate chordate, Ciona intestinalis. The Ciona heart progenitor lineage is first specified by Fibroblast Growth Factor/Map Kinase (FGF/MapK) activation of the transcription factor Ets1/2 (Ets). Through microarray analysis of sorted heart progenitor cells, we identified the complete set of… CONTINUE READING
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