Initial conditions of psychotropic drug response: studies of serotonin transporter long promoter region (5-HTTLPR), serotonin transporter efficiency, cytokine and kinase gene expression relevant to depression and antidepressant outcome.

@article{Rausch2005InitialCO,
  title={Initial conditions of psychotropic drug response: studies of serotonin transporter long promoter region (5-HTTLPR), serotonin transporter efficiency, cytokine and kinase gene expression relevant to depression and antidepressant outcome.},
  author={Jeffrey L. Rausch},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  year={2005},
  volume={29 6},
  pages={1046-61}
}
  • Jeffrey L. Rausch
  • Published 2005 in
    Progress in neuro-psychopharmacology & biological…
The Hypothesis of Initial Conditions posits that differences in psychotropic drug response result from individual differences in receptor site kinetics, and differences in the sensitivity of downstream receptor-linked responses. This work examines data consistent with the hypothesis, specific to genetic and kinetic differences of the serotonin (5-HT) transporter (SERT), as they may be linked to divergent antidepressant response (ADR). The mechanisms for divergent ADR in association with… CONTINUE READING
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