Initial combination therapy with metformin and colesevelam for achievement of glycemic and lipid goals in early type 2 diabetes.

@article{Rosenstock2010InitialCT,
  title={Initial combination therapy with metformin and colesevelam for achievement of glycemic and lipid goals in early type 2 diabetes.},
  author={Julio Rosenstock and Vivian A. Fonseca and W Timothy Garvey and R. Goldberg and Yehuda Handelsman and Stacey L Abby and Yu-Ling Lai and Xiaoping Jin and Soamnauth Misir and Sukumar Nagendran and Michael R. Jones},
  journal={Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists},
  year={2010},
  volume={16 4},
  pages={629-40}
}
OBJECTIVE To evaluate the efficacy and safety of initial combination therapy with metformin plus colesevelam in patients with early type 2 diabetes. METHODS In this 16-week, randomized, double-blind, placebo-controlled study, adults with type 2 diabetes (hemoglobin A1c [A1C] values of 6.5% to 10.0%) and hypercholesterolemia (low-density lipoprotein cholesterol [LDL-C] levels > or =100 mg/dL) were randomly assigned (1:1) to colesevelam (3.75 g/d) or placebo in combination with open-label… CONTINUE READING
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