Initial cervical dilation and the association of the success of atosiban

  title={Initial cervical dilation and the association of the success of atosiban},
  author={Mohamed A. Khalil and Rabe’a SaadFirst Name and Abdullah Al Ibrahim},
  journal={International Journal of Pregnancy \& Child Birth},
Preterm birth is defined as delivery at less than 37 weeks gestation and is the leading cause of perinatal morbidity and mortality.1 Preterm birth (birth occurring before 37 weeks of gestation) is a global public health challenge, with 15 million infants born preterm every year and an estimated 35% of deaths in the first 4 weeks of life are directly attributable to prematurity.2 In 2013, preterm birth complications were the leading cause of death of the estimated 6.3 million liveborn children… 

Tables from this paper

Evaluation of Atosiban Therapy in the Management of Preterm Labour in Indian Patients

In patients with threatened preterm birth, 48 hour tocolysis with atosiban was found to be safe and effective in preventing imminent pre term birth even when it was a twin pregnancy or associated with co-morbidities.



Preterm labour. Pharmacological prevention of prematurity.

  • K. Groom
  • Medicine
    Best practice & research. Clinical obstetrics & gynaecology
  • 2007
The acute treatment of premature labour is successful for delaying delivery for short periods of time, and the use of progesterone in women with a history of very early preterm labour is likely to be beneficial for preventing pre term labour.

The preterm parturition syndrome

The evidence indicating that the pathological processes implicated in the preterm parturition syndrome include: intrauterine infection/inflammation; uterine ischaemia; (3) uterine overdistension; (4) abnormal allograft reaction; (5) allergy; (6) cervical insufficiency; and (7) hormonal disorders (progesterone related and corticotrophin‐releasing factor related).

An oxytocin receptor antagonist (atosiban) in the treatment of preterm labor: a randomized, double-blind, placebo-controlled trial with tocolytic rescue.

The treatment of patients in preterm labor with atosiban resulted in prolongation of pregnancy for up to 7 days for those at a gestational age > or =28 weeks, and this occurred with a low rate of maternal-fetal adverse effects.

National, regional and worldwide estimates of preterm birth rates in the year 2010 with time trends for selected countries since 1990: a systematic analysis and implications

  • Lancet
  • 2012

Tocolytic therapy: a metaanalysis and decision analysis

  • Obstet Gynecol
  • 2009

Global, regional, and national causes of child mortality in 2000-2010: an updated systematic analysis

  • Lancet
  • 2012