Initial biological qualification of SBDP-145 as a biomarker of compound-induced neurodegeneration in the rat.

@article{Pritt2014InitialBQ,
  title={Initial biological qualification of SBDP-145 as a biomarker of compound-induced neurodegeneration in the rat.},
  author={Michael L Pritt and David G. Hall and William H. Jordan and Darryl W Ballard and Kevin K W Wang and Uwe R. M{\"u}ller and David E. Watson},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2014},
  volume={141 2},
  pages={
          398-408
        }
}
Detection of compound-related neurodegeneration is currently limited to brain histopathology in veterinary species and functional measurements such as electroencephalography and observation of clinical signs in patients. The objective of these studies was to investigate whether concentrations of spectrin breakdown product 145 (SBDP-145) in cerebrospinal fluid (CSF) correlate with the severity of neurodegeneration in rats administered neurotoxic agents, as part of a longer term objective of… CONTINUE READING

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