Initial autophagic protection switches to disruption of autophagic flux by lysosomal instability during cadmium stress accrual in renal NRK-52E cells

Abstract

The renal proximal tubule (PT) is the major target of cadmium (Cd2+) toxicity where Cd2+ causes stress and apoptosis. Autophagy is induced by cell stress, e.g., endoplasmic reticulum (ER) stress, and may contribute to cell survival or death. The role of autophagy in Cd2+-induced nephrotoxicity remains unsettled due to contradictory results and lack of… (More)
DOI: 10.1007/s00204-017-1942-9

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Cite this paper

@article{Lee2017InitialAP, title={Initial autophagic protection switches to disruption of autophagic flux by lysosomal instability during cadmium stress accrual in renal NRK-52E cells}, author={W.-K. Lee and S Probst and Mitzi Paola Santoyo-S{\'a}nchez and Wasim A. Al-Hamdani and Ian Diebels and J.-K. von Sivers and Evan M Kerek and Elmar J Prenner and Frank Th{\'e}venod}, journal={Archives of Toxicology}, year={2017}, volume={91}, pages={3225-3245} }