Initial- and processive-cut products reveal cellobiohydrolase rate limitations and the role of companion enzymes.

@article{Fox2012InitialAP,
  title={Initial- and processive-cut products reveal cellobiohydrolase rate limitations and the role of companion enzymes.},
  author={Jerome M. Fox and Seth E Levine and Douglas S Clark and Harvey W. Blanch},
  journal={Biochemistry},
  year={2012},
  volume={51 1},
  pages={442-52}
}
Efforts to improve the activity of cellulases, which catalyze the hydrolysis of insoluble cellulose, have been hindered by uncertainty surrounding the mechanistic origins of rate-limiting phenomena and by an incomplete understanding of complementary enzyme function. In particular, direct kinetic measurements of individual steps occurring after enzymes adsorb to the cellulose surface have proven to be experimentally elusive. This work describes an experimental and analytical approach, derived… CONTINUE READING

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