Initial accumulation of platelets during arterial thrombus formation in vivo is inhibited by elevation of basal cAMP levels.


Platelet accumulation at sites of vascular injury is the primary event in arterial thrombosis. Initial platelet accrual into thrombi is mediated by interactions of platelet adhesion receptors with ligands on the injured endothelium or in the sub-endothelial matrix. The role of intracellular signals in initial platelet accumulation at sites of endothelial… (More)


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