Initial Use of Ambrisentan plus Tadalafil in Pulmonary Arterial Hypertension.

  title={Initial Use of Ambrisentan plus Tadalafil in Pulmonary Arterial Hypertension.},
  author={Nazzareno Gali{\`e} and Joan Albert Barber{\`a} and Adaani E. Frost and Hossein Ardeschir Ghofrani and Marius M. Hoeper and Vallerie V McLaughlin and Andrew J. Peacock and G{\'e}rald Simonneau and J-L. Vachiéry and Ekkehard Gr{\"u}nig and Ronald J. Oudiz and Anton Vonk-Noordegraaf and R. James White and Christiana Blair and Hunter Campbell Gillies and Karen L. Miller and Julia H N Harris and Jonathan Langley and Lewis J. Rubin},
  journal={The New England journal of medicine},
  volume={373 9},
BACKGROUND Data on the effect of initial combination therapy with ambrisentan and tadalafil on long-term outcomes in patients with pulmonary arterial hypertension are scarce. METHODS In this event-driven, double-blind study, we randomly assigned, in a 2:1:1 ratio, participants with World Health Organization functional class II or III symptoms of pulmonary arterial hypertension who had not previously received treatment to receive initial combination therapy with 10 mg of ambrisentan plus 40 mg… 

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