Initial National Cancer Institute studies on mutagenesis as a prescreen for chemical carcinogens: an appraisal.

@article{Poirier1979InitialNC,
  title={Initial National Cancer Institute studies on mutagenesis as a prescreen for chemical carcinogens: an appraisal.},
  author={Lionel A. Poirier and Frederick Joseph de Serres},
  journal={Journal of the National Cancer Institute},
  year={1979},
  volume={62 4},
  pages={919-26}
}
The efficacy of several in vitro and in vivo assays to detect carcinogens from a list of compounds was evaluated. Salmonella and polymerase A-deficient Escherichia coli in vitro were the most effective systems studied. Together they detected 82% of the organic carcinogens tested. Potential prescreening systems, which were thought to be currently insufficiently sensitive for the routine screening of potential carcinogens, included a) the development of resistance to thymidine overloading… CONTINUE READING