Initial Characterization of PMMA as a Discriminative Stimulus1

@article{Glennon1997InitialCO,
  title={Initial Characterization of PMMA as a Discriminative Stimulus1
},
  author={Richard A Glennon and Richard Young and Małgorzata Dukat and Yulin Cheng},
  journal={Pharmacology Biochemistry and Behavior},
  year={1997},
  volume={57},
  pages={151-158}
}
The phenylisopropylamine PMMA or N-methyl-1-(4-methoxyphenyl)-2-aminopropane, a structural hybrid of paramethoxyamphetamine (PMA) and methamphetamine, has been previously shown to unexpectedly lack amphetamine-like or hallucinogen-like stimulus properties in animals. For example, in tests of stimulus generalization, neither a (+)amphetamine stimulus nor a DOM stimulus generalized to PMMA. It has also been shown, however, that stimulus generalization does occur in animals trained to discriminate… Expand
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References

SHOWING 1-10 OF 37 REFERENCES
A preliminary behavioral investigation of PMMA, the 4-methoxy analog of methamphetamine
TLDR
The present results suggest that while PMMA may produce central effects it does not appear to behave as a simple amphetamine-like agent. Expand
Stimulus properties of 1-(3,4-methylenedioxyphenyl)-2-aminopropane (MDA) analogs
TLDR
The present results are consistent with other reports in the literature suggesting that the psychoactive effects of certain MDA derivatives may be other than simply amphetamine- or DOM-like. Expand
Stimulus properties of ring-methyl amphetamine analogs
TLDR
It is concluded that oTAP is capable of producing amphetamine-like stimulus effects and that it is approximately one-tenth as potent as (+)amphetamine; however, because the partial generalization produced by mTAP and pTAP was followed by disruption of behavior at slightly higher doses, it cannot be reliably stated that these latter two isomers lack amp methamphetamine-like character. Expand
MDMA-like stimulus effects of alpha-ethyltryptamine and the alpha-ethyl homolog of DOM.
  • R. Glennon
  • Medicine
  • Pharmacology, biochemistry, and behavior
  • 1993
TLDR
This is the first demonstration that classical hallucinogens can produce MDMA-like effects upon homologation and that MDMA- like stimulus effects can be associated with an indolylalkylamine, and these results continue to support the concept that an intact methylenedioxy ring system is not a structural requirement for drugs to produce MDMA -like effects. Expand
MDMA-like stimulus effects of α-ethyltryptamine and the α-ethyl homolog of DOM
  • R. Glennon
  • Psychology
  • Pharmacology Biochemistry and Behavior
  • 1993
One-carbon homologation of phenylalkylamine or indolylalkylamine or indolylalkylamine hallucinogens containing an α-methyl substituent typically results in a reduction of hallucinogenic potency;Expand
Discriminative stimulus properties of MDA analogs.
TLDR
Rats trained to discriminate (+/-) 2,5-dimethoxy-4-methylphenylisopropylamine (DOM) from saline, using a standard two-lever operant task, were challenged with various doses of MDA and several related agents, suggesting that R(-)- and (+/-)-MDA are capable of producing behavioral (stimulus) effects common to those produced by the training dose. Expand
Investigation of MDMA-related agents in rats trained to discriminate MDMA from saline
TLDR
Results indicate that an intact methylenedioxy ring, such as that found in MDMA but absent in PMMA, is not a prerequisite for MDMA-like activity and further support the notion that ring-opened MDMA metabolites may produce effects that contribute to the actions of MDMA. Expand
Stimulus effects of N-monoethyl-1-(3,4-methylenedioxyphenyl)-2-aminopropane (MDE) and N-hydroxy-1-(3,4-methylenedioxyphenyl)-2-aminopropane (N-OH MDA) in rats trained to discriminate MDMA from saline
TLDR
MDMA-stimulus generalization to MDE, N-OH MDA, but not to (+)amphetamine suggest that 1) MDMA produces effects other than those that may be considered amphetamine-like, and 2) MDE and N- OH MDA are MDMA-like agents with even less of an amp methamphetamine-like component of action than MDMA itself. Expand
A three-lever operant procedure differentiates the stimulus effects of R(-)-MDA from S(+)-MDA.
  • R. Young, R. Glennon
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1996
TLDR
The data support the contention that each optical isomer of MDA can produce a markedly different stimulus effect. Expand
Serotonergic-dopaminergic mediation of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”)
  • M. Schechter
  • Medicine, Psychology
  • Pharmacology Biochemistry and Behavior
  • 1988
TLDR
The results suggest that the effects of MDMA at 20 min postadministration are solely serotonergic in nature, and at 105 min postinjection there appears to be the presence of a weak dopaminergic component. Expand
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