Initial 17beta-estradiol dose for treating vasomotor symptoms.

  title={Initial 17beta-estradiol dose for treating vasomotor symptoms.},
  author={Morris Notelovitz and John P Lenihan and Michael McDermott and Irwin J. Kerber and Nayan Nanavati and J A Arce},
  journal={Obstetrics and gynecology},
  volume={95 5},
OBJECTIVE To compare the efficacy of different doses of 17beta-estradiol (E2) for relief of vasomotor symptoms in menopausal women. METHODS This was a randomized, double-masked, placebo-controlled, 12-week study in which 333 menopausal women with moderate or severe hot flushes were assigned to treatment with 0.25 mg, 0.5 mg, 1 mg, or 2 mg oral micronized 17beta-E2, or placebo. The number and severity of hot flushes were recorded daily. RESULTS There was a significant linear correlation… CONTINUE READING


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