• DOI:10.1042/BST0180974
• Corpus ID: 13373648

Inhomogeneity of skeletal muscle glycogen synthesis upon refeeding following starvation.

@article{Calder1990InhomogeneityOS,
  title={Inhomogeneity of skeletal muscle glycogen synthesis upon refeeding following starvation.},
  author={Philip C. Calder and R. Geddes},
  journal={Biochemical Society transactions},
  year={1990},
  volume={18 5},
  pages={
          974-5
        }
}

• P. Calder, R. Geddes
• Published 1 October 1990
• Biology
• Biochemical Society transactions

more potent than TNFa or IL1 a in inhibiting PG synthesis. Additionally. TNFa-induced inhibition of PG synthesis in control or OA cartilage was relieved slightly by TGFB (10 ng/ml) and t o a greater extent by IGF-1 (100 nglml), although neither growth factor could completely abrogate inhibition. No differences could be detected in the response of OA cartilage t o 1L1 or TNFa compared with control cartilage. I3'S]PG was inhibited to a similar extent and could be only partially, if at all, relieved by simultaneous TGFP or IGF-1 treatment. I t therefore appears that the early changes in PG metabolism in OA cartilage are not brought about by differences in responsiveness of chondrocytes to catabolic cytokines. I . '5andy.J.D.. Adams, M. E..Billingham.M.E.J..Plaas,A.& Muir,H.