Inhibitory threshold for critical-period activation in primary visual cortex

  title={Inhibitory threshold for critical-period activation in primary visual cortex},
  author={M. Fagiolini and T. Hensch},
  • M. Fagiolini, T. Hensch
  • Published 2000
  • Medicine, Biology
  • Nature
  • Neuronal circuits across several systems display remarkable plasticity to sensory input during postnatal development. Experience-dependent refinements are often restricted to well-defined critical periods in early life, but how these are established remains mostly unknown. A representative example is the loss of responsiveness in neocortex to an eye deprived of vision. Here we show that the potential for plasticity is retained throughout life until an inhibitory threshold is attained. In mice… CONTINUE READING
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