Inhibitory signaling of 17β-estradiol in platelet activation: the pivotal role of cyclic AMP-mediated nitric oxide synthase activation.

@article{Wu2010InhibitorySO,
  title={Inhibitory signaling of 17β-estradiol in platelet activation: the pivotal role of cyclic AMP-mediated nitric oxide synthase activation.},
  author={G X Wu and J Lee and Duen-Suey Chou and Thanasekaran Jayakumar and George Hsiao and Wei-Fan Chen and Joen-Rong Sheu},
  journal={European journal of pharmacology},
  year={2010},
  volume={649 1-3},
  pages={140-9}
}
Arterial thromboses are mostly composed of platelets adherent to ruptured endothelial surfaces. Platelets are anucleated cells; therefore, they represent an excellent and unique model to selectively investigate the signaling pathways mediating the nongenomic effects of estrogen. The aim of this study was to examine the signal transduction pathways of 17β-estradiol in preventing platelet activation. In this study, 17β-estradiol (5~10 μM) exhibited more-potent activity of inhibiting platelet… CONTINUE READING

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