Inhibitory signaling blocks activating receptor clustering and induces cytoskeletal retraction in natural killer cells

@inproceedings{Abeyweera2011InhibitorySB,
  title={Inhibitory signaling blocks activating receptor clustering and induces cytoskeletal retraction in natural killer cells},
  author={Thushara P. Abeyweera and Ernesto Merino and Morgan Huse},
  booktitle={The Journal of cell biology},
  year={2011}
}
Natural killer (NK) lymphocytes use a variety of activating receptors to recognize and kill infected or tumorigenic cells during an innate immune response. To prevent targeting healthy tissue, NK cells also express numerous inhibitory receptors that signal through immunotyrosine-based inhibitory motifs (ITIMs). Precisely how signals from competing activating and inhibitory receptors are integrated and resolved is not understood. To investigate how ITIM receptor signaling impinges on activating… CONTINUE READING
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