Inhibitory role of toll-like receptors agonists in Plasmodium yoelii liver stage development.

@article{Chen2009InhibitoryRO,
  title={Inhibitory role of toll-like receptors agonists in Plasmodium yoelii liver stage development.},
  author={Jianchu Chen and Wen-yue Xu and Teng F Zhou and Yan Ding and Jingjing Duan and Faqing Huang},
  journal={Parasite immunology},
  year={2009},
  volume={31 8},
  pages={466-73}
}
It is well known that innate immune plays an important role in controlling the development of Plasmodium liver stage. However, little is known about the role of toll-like receptors (TLR) signalling in the pre-erythrocytic immunity against Plasmodium. Here, we found that pre-treatment with individual TLR agonist pam3CSK4 (TLR2), poly(I:C) (TLR3), LPS (TLR4) and CpG (TLR9) could decrease significantly the liver malaria parasite load in mice for 58%, 63%, 75% and 88% respectively. Moreover, no… CONTINUE READING
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